When your veterinarian diagnoses arthritis in your dog, injectable treatments are often among the first recommendations. Understanding how the available options work helps you have an informed discussion with your vet about the best approach for your dog.
Cartrophen Vet (Pentosan Polysulphate)
Cartrophen Vet has been a mainstay of canine arthritis treatment in Australia for decades. It contains pentosan polysulphate sodium (PPS), which works by:
- Inhibiting enzymes that break down cartilage
- Stimulating production of cartilage building blocks (proteoglycans)
- Improving blood flow to the joint
- Reducing inflammatory mediators
Protocol: Four subcutaneous injections at 3 mg/kg, given weekly. Many vets recommend quarterly repeat courses for ongoing management.
Zydax (Pentosan Polysulphate)
Zydax contains the same active ingredient as Cartrophen (pentosan polysulphate sodium). The differences are primarily in manufacturer and marketing rather than clinical effect. Your veterinarian may prefer one brand based on availability and clinical experience, but both deliver the same therapeutic compound.
Librela (Bedinvetmab)
Librela is a newer approach, approved in Australia in recent years. It is a monoclonal antibody that targets nerve growth factor (NGF), a protein involved in pain signalling:
- Monthly subcutaneous injection
- Targets pain directly rather than the disease process
- Does not repair or protect cartilage
- Some dogs show dramatic pain relief; others respond less
- Cannot be used alongside certain other pain medications
Key Differences
Cartrophen/Zydax address the underlying disease by protecting cartilage and stimulating repair. Librela addresses pain signalling without modifying the disease progression. This is an important distinction: pain relief without cartilage protection means the joint may continue to deteriorate even though the dog appears comfortable.
Where Supplements Fit In
Daily Joint Rejuvenate supplementation complements both approaches:
- With Cartrophen/Zydax: The omega-3 fatty acids in green-lipped mussel provide continuous anti-inflammatory support between injection courses, while the natural glucosamine and chondroitin add to the cartilage-protective effects
- With Librela: Since Librela does not protect cartilage, adding Joint Rejuvenate provides the cartilage support and anti-inflammatory benefits that the injection does not address
Many veterinarians now recommend a multimodal approach: prescription injections for disease modification or pain control, combined with daily natural supplementation for ongoing joint support. This combination provides the most comprehensive management strategy for canine arthritis.
