Scientific Evidence

Our support of green-lipped mussel powder to promote joint health for dogs, horses and cats is based on science.

If you are as passionate about joint health as we are, you may be interested in the following references, many of which have already been mentioned on this website.

Journal Papers

This list of reference links provides access to the latest scientific evidence on joint health in general. The papers included in this list have been published in peer-reviewed journals, which means that they have been reviewed by other experts in the field of veterinary medicine.
Abshirini, M., Coad, J., Wolber, F.M. et al. Green-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review. Inflammopharmacol 29, 925–938 (2021). [https://doi.org/10.1007/s10787-021-00801-2]
Cho, S. H. (2019). Effect of Green Lipped Mussel Extract Oil Complex (Gwanjeolpalpal) on Monosodium Iodoacetate-Induced Osteoarthritis in Animal Model. Journal of The Korean Society of Food Science and Nutrition. [https://agris.fao.org/agris-search/search.do?recordID=KR2019004335]
Miller MR, Abshirini M, Wolber FM, Tuterangiwhiu TR, Kruger MC. Greenshell Mussel Products: A Comprehensive Review of Sustainability, Traditional Use, and Efficacy. Sustainability. 2023; 15(5):3912. [https://doi.org/10.3390/su15053912]
Whitehouse, M. W., Macrides, T. A., Kalafatis, N., Betts, W. H., Haynes, D. R., & Broadbent, J. (1997). Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacology, 5(3), 237–246. [https://doi.org/10.1007/s10787-997-0002-0]
Yang S, Min HK, Park J-S, Na HS, Cho ML, Park S-H (2023) A green-lipped mussel prevents rheumatoid arthritis via regulation of inflammatory response and osteoclastogenesis. PLoS ONE 18(1): e0280601. [https://doi.org/10.1371/journal.pone.0280601]
Zawadzki, M., Janosch, C., & Szechinski, J. (2013). Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. Marine drugs, 11(6), 1920–1935. [https://doi.org/10.3390/md11061920]
This list of reference links provides access to the latest scientific evidence on joint health for dogs. The papers included in this list have been published in peer-reviewed journals, which means that they have been reviewed by other experts in the field of veterinary medicine.

Journal Papers

Bui, L. M., & Bierer, T. L. (2003). Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Veterinary Therapeutics, 4(4), 397-407. [https://europepmc.org/article/med/15136981]
Hielm-Björkman, A., Tulamo, R. M., Salonen, H., & Raekallio, M. (2009). Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus). Evidence-based complementary and alternative medicine : eCAM, 6(3), 365–373. [https://doi.org/10.1093/ecam/nem136]
Rialland, P., Bichot, S., Lussier, B., Moreau, M., Beaudry, F., del Castillo, J. R., Gauvin, D., & Troncy, E. (2013). Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 77(1), 66–74. [https://pubmed.ncbi.nlm.nih.gov/23814358/]
This list of reference links is a valuable resource for veterinarians, horse owners, and anyone else who is interested in learning the latest scientific evidence on joint health for horses. The papers included in this list have been published in peer-reviewed journals, which means that they have been reviewed by other experts in the field of veterinary medicine.

Journal Papers

Cayzer J, Hedderley D, Gray S. A randomized, double-blinded, placebo-controlled study on the efficacy of a unique extract of green-lip mussel (Perna canaliculus) in horses with chronic fetlock lameness attributed to osteoarthritis. Equine Vet J 2012; 44:393–398. [https://pubmed.ncbi.nlm.nih.gov/21883418]

Horse Webinar

Nichols, J. 'Benefits of New Zealand Green Lipped Mussels', (2020), Stride Animal Health. Dr Nichols draws on Cayzer (2012), Zawadzki (2013) and Whitehouse (1997) for the information in this highly informative webinar. [https://www.youtube.com/watch?v=Geh8JVn3-Bo]
I encourage you to explore this list of reference links and learn more about joint health for horses. By understanding the latest scientific evidence, you can make informed decisions about the best way to care for your animal's joints.

If you have any concerns about your dog, horse or cat's joint health, email us at arthritistreatments1@gmail.com
or call us at +61 425 310 625 for a free 15 minute consult.

Don't let Arthritis Slow down your dog, horse, or cat.

Speak with our veterinarian Dr. John Stewart and discover effective solutions. Free for 15 minutes!
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  • I have been using Joint Rejuvenate for the last 6 years as part of my management of arthritis in dogs. It is a cost effective way of contributing to both pain relief and joint regeneration
    Dr Phil McConachya
    Principal Veterinarian
    Pound Road Veterinary Clinic, Victoria
  • Better movement after being warmed up
    We bought Joint Rejuvenate for our 8-year-old quarter horse, Garfield, because he had very stiff and clicky joints. After using the product for two weeks we are very pleased to say he is getting along so much better! He is happy to move along, stretch out, take both left and ride canter leads and his joints are not clicking! Since starting on Joint Rejuvenate, we travelled interstate to Queensland where Garfield and Stephen qualified for the final! Never would we have expected his performance to be of such a high quality until starting on this product!
    Janine & Stephen Fenwick
    Equine Body Therapist & Campdraft Competitor
  • Joint Health for Cats
    I love cats. My vet Dr John wonders why I have 13 of them, 6 of them over 14 years of age. I just kept adopting them when they would come to me as strays. When Dr John needed to have a cat rehomed I could not say no. I have had a lot of success with Joint Rejuvenate.
    Cat Lover, Mary
    Australia
  • dog arthritis treatment
    Before we started our 17 year old border collie on Joint Rejuvenate he was very lame. He could hardly get on his bed from very stiff joints, he was unable to shake as he would lose balance and he could only walk short distances. Since being given 1 flat scoop of Joint Rejuvenate daily, Banjo is getting in and out of his bed, he is shaking again, he is going for walks around the farm and he is following us and the horses when we go for a ride. He is so active again and seems so much happier being able to come with us wherever we go. Thank you so much!
    Janine & Stephen Fenwick
    Equine Body Therapist and Campdraft Competitor
  • Joint Health Dogs
    I was unsure about the extent of improvement a joint product would provide, but got advice from my vet and decided to try one. Since putting Robbie, our elderly terrier on Joint Rejuvenate we have noticed a huge improvement in his limping, stiffness and overall willingness to play.
    Andrew
    Retired Builder
  • Dogs Arthritis Treatments
    Very fast delivery. I am very happy with the product and the price. Our Penny (dog), 12 years old, was getting stiff and sore in her back right hip. So we ordered this and it has improved her hip massively, she doesn’t appear to be in pain any more. I will definitely be ordering again when she’s getting near the end of the jar. Thank you so much for this wonderful product.
    Preet Singh
    Victoria, Australia
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