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Scientific Evidence

Published, peer-reviewed research supporting the use of green-lipped mussel for arthritis treatment in animals.

Journal Papers - Green-Lipped Mussel Research

  • Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel

    Whitehouse MW, Macrides TA, Kalafatis N, Betts WH, Haynes DR, Broadbent J

    Inflammopharmacology (1997)

  • Antiarthritic and anti-inflammatory activity of 5-lipoxygenase and cyclo-oxygenase 2 inhibitors

    Singh S, Majumdar DK

    Indian J Exp Biol (1996)

  • Anti-inflammatory activity of lipid fractions from the New Zealand green-lipped mussel

    Macrides TA, Kalafatis N, Wright PFA

    Letters in Drug Design and Discovery (2004)

  • The effects of Omega-3 Fatty Acids on Articular Cartilage

    Dantes E, Kavanaugh A

    Expert Review of Clinical Immunology (2011)

  • Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis

    Silva S, Sepodes B, Rocha J, et al.

    Journal of Nutritional Biochemistry (2015)

  • Perna canaliculus (the NZ green-lipped mussel) - A review of established anti-arthritic benefits and personal perspectives regarding future therapies

    Whitehouse MW

    Inflammopharmacology (2001)

Dogs - Clinical Studies

  • Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus)

    Hielm-Bjorkman A, Tulamo RM, Salonen H, Raekallio M

    Evidence-Based Complementary and Alternative Medicine (2009)

  • Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis

    Rialland P, Bichot S, Lussier B, Moreau M, Beaudry F, del Castillo JRE, Gauvin D, Troncy E

    Canadian Journal of Veterinary Research (2013)

  • Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs

    Bui LM, Bierer RL

    Veterinary Therapeutics (2003)

Horses - Clinical Studies

Cats - Clinical Studies

While specific clinical trials for green-lipped mussel in cats are limited, the anti-inflammatory properties that benefit dogs and horses also apply to feline patients. Veterinary practitioners report significant improvements in arthritic cats receiving green-lipped mussel supplementation.

Want to Discuss the Science?

Dr John Stewart is available for a free 15-minute veterinary consultation to discuss Joint Rejuvenate and the science behind it.

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