Scientific Evidence

Our support of green-lipped mussel powder to promote joint health for dogs, horses and cats is based on science.

If you are as passionate about joint health as we are, you may be interested in the following references, many of which have already been mentioned on this website.

Journal Papers

This list of reference links provides access to the latest scientific evidence on joint health in general. The papers included in this list have been published in peer-reviewed journals, which means that they have been reviewed by other experts in the field of veterinary medicine.
Abshirini, M., Coad, J., Wolber, F.M. et al. Green-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review. Inflammopharmacol 29, 925–938 (2021). [https://doi.org/10.1007/s10787-021-00801-2]
Cho, S. H. (2019). Effect of Green Lipped Mussel Extract Oil Complex (Gwanjeolpalpal) on Monosodium Iodoacetate-Induced Osteoarthritis in Animal Model. Journal of The Korean Society of Food Science and Nutrition. [https://agris.fao.org/agris-search/search.do?recordID=KR2019004335]
Miller MR, Abshirini M, Wolber FM, Tuterangiwhiu TR, Kruger MC. Greenshell Mussel Products: A Comprehensive Review of Sustainability, Traditional Use, and Efficacy. Sustainability. 2023; 15(5):3912. [https://doi.org/10.3390/su15053912]
Whitehouse, M. W., Macrides, T. A., Kalafatis, N., Betts, W. H., Haynes, D. R., & Broadbent, J. (1997). Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacology, 5(3), 237–246. [https://doi.org/10.1007/s10787-997-0002-0]
Yang S, Min HK, Park J-S, Na HS, Cho ML, Park S-H (2023) A green-lipped mussel prevents rheumatoid arthritis via regulation of inflammatory response and osteoclastogenesis. PLoS ONE 18(1): e0280601. [https://doi.org/10.1371/journal.pone.0280601]
Zawadzki, M., Janosch, C., & Szechinski, J. (2013). Perna canaliculus lipid complex PCSO-524™ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. Marine drugs, 11(6), 1920–1935. [https://doi.org/10.3390/md11061920]
This list of reference links provides access to the latest scientific evidence on joint health for dogs. The papers included in this list have been published in peer-reviewed journals, which means that they have been reviewed by other experts in the field of veterinary medicine.

Journal Papers

Bui, L. M., & Bierer, T. L. (2003). Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Veterinary Therapeutics, 4(4), 397-407. [https://europepmc.org/article/med/15136981]
Hielm-Björkman, A., Tulamo, R. M., Salonen, H., & Raekallio, M. (2009). Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus). Evidence-based complementary and alternative medicine : eCAM, 6(3), 365–373. [https://doi.org/10.1093/ecam/nem136]
Rialland, P., Bichot, S., Lussier, B., Moreau, M., Beaudry, F., del Castillo, J. R., Gauvin, D., & Troncy, E. (2013). Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 77(1), 66–74. [https://pubmed.ncbi.nlm.nih.gov/23814358/]
This list of reference links is a valuable resource for veterinarians, horse owners, and anyone else who is interested in learning the latest scientific evidence on joint health for horses. The papers included in this list have been published in peer-reviewed journals, which means that they have been reviewed by other experts in the field of veterinary medicine.

Journal Papers

Cayzer J, Hedderley D, Gray S. A randomized, double-blinded, placebo-controlled study on the efficacy of a unique extract of green-lip mussel (Perna canaliculus) in horses with chronic fetlock lameness attributed to osteoarthritis. Equine Vet J 2012; 44:393–398. [https://pubmed.ncbi.nlm.nih.gov/21883418]

Horse Webinar

Nichols, J. 'Benefits of New Zealand Green Lipped Mussels', (2020), Stride Animal Health. Dr Nichols draws on Cayzer (2012), Zawadzki (2013) and Whitehouse (1997) for the information in this highly informative webinar. [https://www.youtube.com/watch?v=Geh8JVn3-Bo]
I encourage you to explore this list of reference links and learn more about joint health for horses. By understanding the latest scientific evidence, you can make informed decisions about the best way to care for your animal's joints.

If you have any concerns about your dog, horse or cat's joint health, email us at arthritistreatments1@gmail.com
or call us at +61 425 310 625 for a free 15 minute consult.

Don't let Arthritis Slow down your dog, horse, or cat.

Speak with our veterinarian Dr. John Stewart and discover effective solutions. Free for 15 minutes!
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